Andrographis paniculata (Burm.f.) Nees
Traditional Knowledge
Useful plant parts :
Whole plant and leaf
Uses in traditional medicine :
- An infusion is taken to treat fever and is considered as an antidote for cobra venom
- Decoction of the aerial parts is used as an appetiser
- Principal ingredient of a bitter tonic and febrifuge
- Leaves with other spices used for relieving gripping and loss of appetite in infants
Scientific Research
Chemical constituents:
Terpenoids: andrographolide and neoandrographolide, syringaresinol, terpene and iridoid glucosides: andrographidine A-G, acanthoside B, andrographiside, neoandrographiside, andropanoside, didehydroandrographiside derivatives, curvifloruside F, 6-epi-8-0-acetylharpagide, iridoid glycosides: procumbide, procumboside from plant
Bioactivity :
Ethanol extract of leaves: antioxidative, gastroprotective, a-glucosidase and a-amylase inhibitor, antivenom
Clinical:
Safe and efficacious treatment for uncomplicated upper respiratory tract infections; Tablet (Paractin) made of extract from aerial parts (30% andrographolide) is effective against rheumatoid arthritis
References : Burgos, R. A. et al., (2009), Efficacy of an Andrographis paniculata composition for the relief of rheumatoid arthritis symptoms: a prospec- tive randomized placebo-controlled trial, Medicine, 28(8), 931-946. Chao, W. W. and Lin, B. F., (2010), Isolation and identification of bioactive compounds in Andrographis paniculata (Chuanxinlian), Chao and Lin Chinese Medicine, 5(17). Coon, J. T. and Ernst, E., (2004), Andrographis paniculata in the Treatment of Upper Respiratory Tract Infections: A Systematic Review of Safety and Efficacy, Planta Med, 70(4), 293-298. Hapuarachchi, S. D. et al., (2013), Andrographidine G, a new flavone glucoside from Andrographis paniculata, Nat Prod Commun, 8(3), 333-4. Premendran, S. J. et al., Anti-cobra venom activity of plant Andrographis paniculata and its comparison with polyvalent anti-snake venom, J Nat Sci Biol Med, 2(2), 198-204. Subramanian, R. et al., (2008), In vitro alpha-glucosidase and alpha- amylase enzyme inhibitory effects of Andrographis paniculata extract and andrographolide, Acta Biochim Pol, 55(2), 391-8. Wasman, S. Q. et al., (2011), Antioxidant and gastroprotective activities of Andrographis paniculata (Hempedu Bumi) in Sprague Dawley rats, Indian Journal of Experimental Biology, 49(10), 767-772. Yang, T. et al., (2013), Hypolipidemic effects of andrographolide and neoandrographolide in mice and rats, Phytother Res, 27(4), 618-23.
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