Crinum asiaticum L.
Traditional Knowledge
Useful plant parts :
Bulb
Uses in traditional medicine :
- Paste prepared from finely ground fresh bulbs is applied around swellings and inflamed joints
Scientific Research
Chemical constituents:
Alkaloidal conjugates,C16-acyloxy derivative: palmilycorine, acylglucosyloxy derivative: lycoriside, schiff’s base: isocraugsodine from fruits; pyrrolophenanthridone alkaloids: criasiaticidine A, pratorimine, lycorine and flavonoids from bulbs; Amaryllidaceae alkaloids: seco-isopawellaminone, crinamine, crinamine-N-oxide, hamayane, hippadine, plaforinine, norgalanthamine and epinorgalanthamine from aerial parts
Bioactivity :
Methanol extract of plant: anti-inflammatory; crinamine: hypoxia inducible factor-1 (HIF-1) inhibitor; nor gallanthamine: promotes hair growth
Clinical:
References : Ghosal, S. et al., (1985), Palmilycorine and lycoriside: acyloxy and acylglucosyloxy alkaloids from Crinum asiaticum, Phytochemistry, 24(11), 2703-2706. Ghosal, S., et al., (1988), Isocraugsodine, an n-arylidenephenethylamine from Crinum asiaticum and its e-z isomerism, Phytochemistry, 27(6), 1849-1852. Kim, Y. H. et al., (2006), Crinamine from Crinum asiaticum var. japonicum Inhibits Hypoxia Inducible Factor-1 Activity But Not Activity of Hypoxia Inducible Factor-2, Chemical and Pharmaceutical Bulletin, 29(10), 2140-2142. Kim, S. C. et al., (2010), Promotion effect of norgalanthamine, a component of Crinum asiaticum, on hair growth, European Journal of Dermatology, 20(1), 42-8. Kogure, N. et al., (2011), Two new alkaloids from Crinum asiaticum var sinicum, Chem Pharm Bull, 59(12), 1545-1548. Min, B. S. et al., (2001), Cytotoxic Alkaloids and a Flavan from the Bulbs of Crinum asiaticum var. japonicum, Chemical and Pharmaceutical Bulletin, 49(9), 1217-1219. Samud, A. M. et al., (1999), Anti-inflammatory activity of Crinum asiaticum plant and its effect on bradykinin-induced contractions on isolated uterus, Immunopharmacology, 43(2-3), 311-316.
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