Jatropha gossypiifolia L.
Traditional Knowledge
Useful plant parts :
Leaf, seed kernel and root
Uses in traditional medicine :
- Crushed young leaves are used to treat swollen breasts
- Lower doses of ground seed kernel are taken as a laxative
- One tea spoon of root decoction is taken once a day for constipation
Scientific Research
Chemical constituents:
Diterpenes: jatrophone derivatives, abiodone, jatrophenone from roots; coumarino-lignoid: cleomiscosin A from stems; cyclic heptapeptide: cyclogossine A from latex
Bioactivity :
Alcohol extract of aerial parts: inhibits cancer cell growth, aqueous and alcohol extracts of plant: elicit hypotension and vasorelaxant activity; antimalarial; abiodone: anti cancer; jatrophenone: antibacterial; ethyl acetate and methanol extracts of plant: acetylcholinesterase inhibitor
Clinical:
References : Abreu, I. C. et al., (2003), Hypotensive and vasorelaxant effects of ethanolic extract from Jatropha gossypiifolia L. in rats, Fitoterapia, 74(7-8), 650-657. Das, B. et al., (2003), Cleomiscosin A, a coumarino-lignoid from Jatropha gossypifolia, Biochemical Systematics and Ecology, 31(10), 1189-1191. Falodun, A. et al., (2012), A novel anticancer diterpenoid from Jatropha gossypifolia, Nat Prod Commun, 7(2), 151-2. Feitosa, C. M. et al., (2011), Acetylcholinesterase inhibition by somes promising Brazilian medicinal plants, Braz J Biol, 71(3), 783-9. Gbeassor, M. et al., (1989), Antimalarial effects of eight African medicinal plants, J Ethnopharmacol, 25(1), 115-8. Horsten, S. F. et al., (1996), Cyclogossine A: a novel cyclic heptapeptide isolated from the latex of Jatropha gossypifolia, Planta Med, 62(1), 46-50. Ravindranath, N. et al., (2003), Jatrophenone, a novel macrocyclic bioactive diterpene from Jatropha gossypifolia, Chem Pharm Bull, 51(7), 870-1. Kupchan, S. M. et al., (1970), Jatrophone, a novel macrocyclic diterpe- noid tumor inhibitor from Jatropha gossypiifolia, Journal of the American Chemical Society, 92(14), 4476-4477. Taylor, M. et al., (1983), New antileukemic Jatrophone derivatives from Jatropha gossypifolia: Structural and stereochemical assignment through nuclear magnetic resonance spectroscopy, Journal of the American Chemical Society, 105(10), 4.
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