Thevetia peruviana (Pers.) Merr.

Apocynaceae

Common Names:
Kaha kaneru (S)
Manjal arali (T)
Lucky nut, Yellow Oleander (E)
Ashvaha (Sa)

Traditional Knowledge

Useful plant parts :
Seed

Uses in traditional medicine :

Used in cardiac insufficiency with other ingredients

Scientific Research

Chemical constituents:

Flavonoid glucosides: pervianoside I-III and kaempferol, thevitile and quercetin derivatives and iridoid glucosides: theviridoside derivatives from leaves; cardenolide glycoside: thevefolin, ursane type triterpenes: peruvianursenyl acetate A–C, lupidienyl acetate, α-amyrin acetate and lupeol acetate from plant

Bioactivity :

Thevefolin: reversal effect on tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) resistance in human gastric adenocarcinoma cells; n-hexane or dichloromethane extract of seeds: antifungal photoactivity

Clinical:

Note :

Found only under cultivation

Caution : Seeds are highly poisonous

References :

Abe, F. et al, (1995), Flavonol sinapoyl glycosides from leaves of Thevetia peruviana, Phytochemistry, 40(2), 577–581

Abe, F. et al, (1995), Minor iridoids from Thevetia peruviana, Phytochemistry, 38(3), 793–794.

Ali, M. et al., (2000), New ursane-type triterpenic esters from the stem bark of Thevetia peruviana, Pharmazie, 55(5), 385-9.

Gata-Gonçalves, L. et al., (2003), Photoactive extracts from Thevetia peruviana with antifungal properties against Cladosporium cucumeri- num, Journal of Photochemistry and Photobiology B: Biology, 70(1), 51-54.

Miyagawa, T. et al., (2009), Cardenolide Glycosides of Thevetia peruviana and Triterpenoid saponins of Sapindus emarginatus as TRAIL Resistance-Overcoming Compounds, Journal of Natural Products, 72 (8), 1507–1511.

Tewtrakul, S. et al., (2002) ,Flavanone and Flavonol Glycosides from the Leaves of Thevetia peruviana and Their HIV-1 Reverse Transcriptase and HIV-1 Integrase Inhibitory Activities, Chemical & Pharmaceutical Bulletin, 50(5), 630.

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